The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition
Published in Nature Cell Biology, 2015
Recommended citation: Sperber H, Mathieu J, Wang Y, Ferreccio A, Hesson J, Xu Z, Fischer KA, Devi A, Detraux D, Gu H, Battle SL, Showalter M, Valensisi C, Bielas JH, Ericson NG, Margaretha L, Robitaille AM, Margineantu D, Fiehn O, Hockenbery D, Blau CA, Raftery D, Margolin AA, Hawkins RD, Moon RT, Ware CB, Ruohola-Baker H: The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition. Nat Cell Biol. 17:1523-1535, 2015 https://www.nature.com/articles/ncb3264
Integrated trancriptomic, epigenomic, and metabolomic data and discovered that NNMT, a metabolic enzyme, regulates H3K27me3 methylation levels in naive to primed transition.